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QUESTION OF THE WEEK

Dr. Donovan's Articles

QUESTION OF HAIR BLOGS


Should I Use Finasteride for Hairline Maturation?

There are two common changes to the frontal hairline that young men can observe. One is known as hairline maturation and the second is male pattern hair loss (also known as androgenetic alopecia). Both are a cause of worry to patients and both are commonly misdiagnosed.

 

Hairline maturation

Hairline maturation is a normal process that occurs between age 15-27 whereby a small amount of hair recession occurs in the very frontal hairline and a slight amount of recession of the temple is observed. This is generally 1 cm above the highest forehead wrinkle in the centre and 1.5 inches in the temples. In male balding recession occurs to greater degrees.

 

Treatment of hairline maturation and male balding

The distinction between the two conditions (hairline maturation vs balding) is important as there are no medical treatments for hairline maturation. Male balding can be addressed with treatments such as finasteride or minoxidil as well as others too.

Finasteride (Propecia and generics) and minoxidil (Rogaine and generics) are FDA approved for male pattern balding. These treatments do not have any effect on normal male hairline maturation. One may want to check with a physician of concerns exist about signs of early male balding. The best thing that can be done in early stages of hair loss is frequent scalp photography every 4-6 months. This is extremely helpful to track changes in the hairline and get a sense of the degree of hairline maturation and balding a person might have.


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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Androgenetic alopecia in women: Can I still have it if my hormones are low?

AGA in Women with Low Androgens

I'm often asked on various blogs and posts how it's possible to have androgenetic alopecia if a woman's androgen levels are normal or low. Many individuals have received a diagnosis of androgenetic alopecia and once their blood tests return normal, then have questions:

Is the diagnosis wrong?

How could I possibly have AGA if my androgens (testosterone, DHEAS, etc) is normal?

 

AGA in Women is best called FPHL

One must always keep in mind that androgenetic hair loss in women has much less to do with male hormones than it does in men. MOST women with AGA have normal hormone levels. In fact, about 90 % have normal hormone (androgen) levels. Treatments for AGA in women can still be helpful in many despite normal or low - normal levels. For this reason, many dermatologists choose to call female androgenetic alopecia "female pattern hair loss (FPHL)" rather than ANDROgenetic alopecia to de-emphasize the role of androgens.  

 

Summary

There are many complex mechanisms that lead to the development of AGA in women. For many women, androgenetic alopecia has little to do with androgens. For some it has a lot to do with androgens and for some it probably has nothing to do with androgens.  


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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Changes in Hair Texture

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What causes hair to become wavier?

There are several reasons for an individual with straight hair to find their hair has become wavier or even curlier. Causes include age related genetic programming, endocrine disorders (ie hypothyroidism), scarring alopecias, hair trauma (from heat or chemicals), androgenetic alopecia, medications (ie retinoids, minoxidil) and a variety of inflammatory disorders.


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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Androgenetic Alopecia and Height

Baldness Associated with Shorter Height

Is there a link between the height of a man and his chances of developing androgenetic hair loss (male pattern balding)? 

Recent studies have suggested that answer is yes. Researchers at the University of Bonn performed an extensive study of over 20,000 men (10,000 with hair loss compared to 10,000 without hair loss) and concluded that many of the genes controlling male balding are also linked to being shorter in height.

The researchers discovered 63 genetic changes that increase a man’s risk of developing early onset balding. These same genetic changes were linked with a greater likelihood of being shorter.

This study confirms that hair loss is not an isolated phenomenon but rather controlled by genes that also determine one’s height and various aspects of health.

 

Reference

Heilman-Heimbach et al. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nature Communications, 2017; 8: 14694 DOI


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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Trichogram: An Older Less Commonly Used Technique

The "trichogram" is an older technique developed in 1957 for assessing hair loss. It involves quickly pulling out the roots of 50-70 hairs. The hairs are all placed on a glass slide and examined under the microscope.

By carefully comparing an affected area of hair loss to a presumed unaffected area alot of information can be ascertained. In androgenetic alopecia, there is a marked increase in the proportion of telogen hairs in the frontal scalp (as well as a variation in hair shaft diameter) compared to the occipital scalp. In a pure telogen effluvium the trichogram results are similar in the front and back of the scalp.

A trichogram can provide helpful information in assessing active alopecia area (where an increase in dystrophic hairs are seen) and hair loss from various toxins.

The technique is not commonly used these days as dermoscopy (trichoscopy) has provided a more sensitive and non invasive means of assessing complex scalp disorders.


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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What cells play key roles in hair growth?

What cells play key roles in hair growth?.png

If you've ever gone deep into the basement of a large building, factory or even a house, you will likely be amazed at how complex the machinery, wires, circuits that all work together are to make the building function optimally.

As far as the hair follicle goes, it takes a considerable amount of coordination by many cell types to finally produce a normal hair fiber. The dermal papilla (or "DP") has an important role in making it all happen.

The DP is found at the base of the hair follicle. It is made up of a group of very specialized cells known as fibroblasts.

The DP is an important control centre for the hair follicle. It tells another collection of cells known as the "hair matrix" exactly what to do in order to make a hair fiber.

The more cells the DP contains and the more active it is .... the bigger and wider the hair follicle that will be produced. 

The DP has the remarkable potential to form brand new hairs when transplanted into other areas of the skin. DP are therefore said to be "trichogenic" (hair forming). One day, it could theoretically be possible to take a patient's skin and increase the number of DP cells they have and inject them back into their scalp. This could lead to an endless supply of hairs.


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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Creatine and Hair Loss

Creatine and Hair Loss.png

There are many potential reasons for hair loss in individuals who use training supplements. Creatine is frequently used as an 'ergogenic' training aid to enhance performance. Although there is no definitive proof, I'd like to outline why it certainly might cause hair loss in those with a 'genetic susceptibility' to balding.

In a study from South Africa 20 college-aged rugby players participated in a double blind study. Subjects loaded with creatine (25 g/day) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine). The researchers looked at serum testosterone and DHT levels at baseline and then at 7 and 21 days. After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 2 weeks maintenance. Testosterone levels were unchanged.

While this data does not prove anything about hair loss, it does suggest that the higher DHT could provide a negative impact on hair loss for individuals who are predisposed to androgenetic alopecia (male balding and female thinning). Not all studies have suggested a negative impact on hormone parameters. A study completed in 2004 suggested that creatine supplementation actually decreased the free androgen index after 3 weeks of use. A 2001 study of 11 men did not find differences in serum testosterone in men receiving 10 g of creatine. However, serum cortisol levels were higher after creatine use during the resting period. 

Conclusion

We don't know if creatine supplementation promotes hair loss. One must at least consider the possibility that changes in DHT and even cortisol could have a negative impact on hair loss. 

Reference

van der Merwe J, et al. Clin J Sport Med. 2009.

Volek JS, et al. Eur J Appl Physiol. 2004.

Eijnde BO, et al. Med Sci Sports Exerc. 2001.


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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Minoxidil (Rogaine/Regaine): Do I really need to use forever?

I'm often asked if a patient needs to use their minoxidil (Rogaine/Regaine, etc) "forever." The answer is sometimes yes and in other cases the answer is "no." It really depends on the diagnosis and a few details specific to each patient. Here are a few examples.

 

Androgenetic Alopecia

Use forever?: Yes

If the patient has androgenetic alopecia (male balding and female thinning), he or she will need to use minoxidil forever. If minoxidil is stopped, the hair will return to the way it once was and progressively get worse. In fact, all treatments for androgenetic alopecia are the same - use is forever. 

 

Telogen Effluvium

Use forever?: Usually not

Patients with telogen effluvium or "excessive" daily shedding from a trigger such as low iron, thyroid problems or a crash diet often don't even need minoxidil. (I’m not a big fan of getting people to use minoxidil in telogen effluvium is the cause is known).

But the patient will often use to encourage more rapid resolution of the hair loss. Once the "trigger" has been addressed and treated, hair shedding usually slows down and eventually stops. Minoxidil can be used until the shedding returns back to a normal rate and them for a few months after. A patient who uses minoxidil after a crash diet will find that shedding reduces to normal once the diet is improved. If minoxidil was used it can be stopped in 6-13 months without the patient experiencing a return of the shedding. In this case minoxidil use is not forever. There are some forms of shedding which continue on and on despite fixing any known "trigger." We call this chronic idiopathic telogen effluvium and in such cases minoxidil may be needed long term for many years (1-15 years… or more!). Generally though even in such cases of chronic idiopathic telogen effluvium the minoxidil can be stopped.

In summary, for most patients with telogen effluvium, use of minoxidil is NOT forever. The goal of treatment is to treat the cause of the shedding (like the low iron or the thyroid problem!)

 

Alopecia areata

Use forever? Usually not

Alopecia areata is an autoimmune condition which can cause hairloss anywhere on the body. Most patients with alopecia areata lose hairs in circles or patches in the scalp. The hair loss in these areas can grow back on its own (we say "spontaneously") or with treatments such as corticosteroids and minoxidil. In most cases, once the hair regrowth is underway, it is possible to stop the minoxidil without the patch of hair loss coming back. 

In summary, for most patients with alopecia areata, use of minoxidil is NOT forever.

 

Scarring alopecia

Use forever? Sometimes 

Although scarring alopecias are commonly seen in my clinic, overall they are relatively uncommon conditions. Most have an immune basis, meaning that some sort of inflammation is generally present underneath the scalp. Treatment with minoxidil alone (as a sole treatment) is never appropriate for patients with "active" scarring alopecia. Minxodil however can be a good add on treatment (adjuvant treatment) to cheer on hairs that are trying hard to push their way through scar tissue in the scalp. I often recommend patients who decided to start minoxidil) and who show some kind of benefit) for scarring alopecias continue to use long term. Scar tissue is permanent and it is helpful if many cases to have minoxidil on board to cheer the hair growth along.

In summary, the decision to use minoxidil forever in scarring alopecias is taken on a case by case basis. For many patients long term use is advised if there is evidence it is actually helping.


This article was written by Dr. Jeff Donovan, a Canadian and US board certified dermatologist specializing exclusively in hair loss.
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