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Hair Shedding

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Hair Shedding

 


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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Diffuse AGA or TE

I posted an answer to a new question on Realself.com

Diffuse AGA or TE


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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Can topical JAK inhibitors be used for the eyelashes?

Today we will continue with a look at the use of JAK inhibitors beginning with a 4 day look at the topical JAK inhibitors for treating alopecia areata. Both oral and JAK inhibitors are not FDA approved for treating alopecia areata but are increasingly used off label. Many reports have emerged of benefits of JAK inhibitors when formulated as creams or lotions rather than pills. Given that topical compounds are likely more safer than oral ones, these studies are extremely important.

Topical treatments for eyelash alopecia areata have largely been limited to bimatoprost (Latisse). In a new study, researchers described a patient with improvement of eyelash growth with application of 1 % ruxolitinib to the upper eyelid skin.


Conclusion

This is an interesting study and clearly more such studies are needed, especially to ensure eye safety. However, topical JAK inhibitors may provide a second option to Latisse in treating eyelash alopecia. 


Reference

Bayarat et al. Topical Janus kinase inhbitors for the treatment of pediatric alopecia areata. J Am Acad Dermatol 2017; 77(1):167-169


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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JAK inhibitors for Alopecia areata: A closer look at the studies to date

JAK inhibitors for AA

This week we will take a look at using topical and oral JAK inhibitors for treating alopecia areata. This includes the drugs tofacitinib (Xeljanz) and ruxolitinib (Jakavi, Jakafi).

A closer look at the Oral JAK Inhibitors

Today, we will start with the oral JAK inhibitors. To date, there have been six reasonably sized studies looking at the benefits of the oral JAK inhibitors. These are summarized in the table. Most of the studies have been done with tofacitinib- the one exception is the study of 12 patients using ruxolitinib by Mackay-Wiggan and colleagues. Two of the 6 studies have been in patients under 18 years - namely the 2017 studies by Craiglow and colleagues Castelo-Soccio and colleagues.
 

Conclusion

The message of all the studies has been the same: use of oral JAK inhibitors in patients with advanced alopecia areata helps, approximately one half achieve cosmetically significant regrowth. 


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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Nape of the neck

I posted an answer to a new question on Realself.com

Nape of the neck


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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Treatment of LPP

I posted an answer to a new question on Realself.com

Treatment of LPP


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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Shedding in AGA

I posted an answer to a new question on Realself.com

Shedding in AGA


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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DUPA or CTE

I posted an answer to a new question on Realself.com

DUPA or CTE


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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Am I Thinning

I posted an answer to a new question on Realself.com

Am I Thinning


Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299
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