Scarring Scarring Alopecia: Oil gland destruction may be a key early stepalopecias are a group of hair loss conditions that lead to permanent hair loss. An example of a scarring alopecia is shown in the photos. Although we know how to recognize these conditions, and we understand how to treat them, we understand very little about their cause.
For years it has be thought that abnormalities developing in the sebaceous glands or "oil glands" of the hair follicle can lead to scarring alopecias. Dr Stephen Lyle and colleages at the University of Massachusetts Medical School set out to determine if the oil glands are affected in patients with various types of scarring alopecias.
The researchers showed that scarring alopecias frequently showed loss of the sebaceous gland. For example, a reduction in sebaceous glands was seen in:
84 % of biopsy specimens from patients with the scarring alopecia lichen planopilaris
77% of biopsy specimens from patients with central centrifugal cicatricial alopecia
100 % of biopsy specimens from patients with follicultis decalvans
In many cases, the sebecaous glands were not only reduced but inflamed as well. For example, inflammation occurring in the sebaceous glands was seen in:
55 % of biopsy specimens from patients with lichen planopilaris
25 % of biopsy specimens from patients with central centrifugal cicatricial alopecia
50 % of biopsy specimens from patients with folliculitis decalvans
Conclusion: These data give further support to the current thinking that inflammation affects the sebaceous gland may be one of the "earliest steps" in the development of scaring alopecia.
Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Vancouver office at 604.283.9299