Thermal Stability of Latisse

Heat Stability of Latisse

I've recently had an large number of questions relating to whether or not Latisse is still safe to use if it has been left in a car for brief periods during elevated temperatures.  Should the Lattise be thrown out? Is it safe to use?

What this question is really asking is what do we know about the stability of Latisse at different temperatures? The stability of a drug as a function of temperature is known as the "thermal stability." Studies to date would suggest that Latisse has remarkable "thermal stability" - at least up to 50 degrees Clecius.

A 2011 study by Johnson and colleagues looked at how the concentration of Latisse (and other prostaglandins) changed when exposed to elevated temperatures including 37 C and 50 C for 3, 6, 9,15 or 30 days. By carefully assaying the concentration of Latisse at each time point the researchers found that there was no change in the concentration of Latisse over time at any of these temperatures. 


Is Latisse safe in my hot car?

To answer this specific question, we really need to know how hot the Latisse was in the car. Of course if the Latissereaches temperatures well above 50 C we enter a grey area and don't fully know the answer based on all studies to date. However Latisse can withstand quite a bit of heat due to its remarkable thermable stability. It is likely to be unaffected to any significant degree following a short period of time at elevated temperature.



Thermal stability of bimatoprost, latanoprost, and travoprost under simulated daily use.

Johnson TV, et al. J Ocul Pharmacol Ther. 2011.

Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Whistler office at 604.283.1887

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