Baricitinib for Alopecia Areata: Eyebrows & Eyelashes Often Significantly Improve Even If Scalp Hair Does not

Significant Eyebrow and Eyelash Improvements in AA Treated with Baricitinib

Authors of a new study set out to re-examine the complete data from the BRAVE AA1 and BRAVE AA2 baricitinib trials to see if eyebrow and eyelash regrowth could still occur to significant levels even if scalp hair regrowth was not occurring. The authors examined eyebrow and eyelash regrowth patterns in patients with AA who had a poor response to scalp regrowth (SALT ≤ 20 response), intermediate response to scalp regrowth (achieved a 30% improvement from baseline (SALT30) without a SALT score ≤ 20), or non-responders (never achieved SALT30).

After 52 weeks of treatment with baricitinib 4 mg treatment, 70 % of scalp responders have complete or near complete regrowth of eyebrows and eyelashes. In contrast, complete or nearly complete regrowth of eyelashes and eyebrows occurred in 50% of patients with intermediate response and 20% of non-responders.

All in all, the authors found that clinically meaningful regrowth in eyebrow and eyelash hair can occur with baricitinib treatment even if scalp hair regrowth does not occur .

REFERENCE

Senna MM et al. Clinical Benefits of Baricitinib Therapy According to Scalp Hair Regrowth in Patients with Severe Alopecia Areata. Dermatol Ther (Heidelb). 2023 Nov 22. doi: 10.1007/s13555-023-01063-2. Online ahead of print.