Methotrexate for Treatment of Alopecia Areata: How long until results are seen?

How long does it take individuals with alopecia areata to see results with methotrexate?

Studies have shown that hair growth can take 2.5-3 months before changes are seen. 2014 studies by Hammerschmidt et al showed that patients who were going to respond often showed responses by the end of the 3rd month (after approximately 180 mg of the drug, taken as 20 mg weekly). This information is important so that patients with alopecia areata don’t stop treatment with MTX too early without giving it the appropriate trial. We don’t see results in a matter of weeks.


Hammerschmidt et al. Efficacy and safety of methotrexate in alopecia areata. An Bras Dermatol 2014; 89; 729-734.

Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Whistler office at 604.283.1887

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