Scalp Dysesthesia, Neurogenic Inflammation and Fibromyalgia

Fibromyalgia as a Cause of Scalp Dysesethesia


The “scalp dysesthesias” are a group of conditions whereby the patient has various types of symptoms in the scalp despite the scalp looking fairly normal. In other words, these are a group of disorders characterized by chronic cutaneous symptoms without objective findings. Patients complain of burning, stinging, or itching, which is often triggered or exacerbated by psychological or physical stress.

SEE: Scalp Dysesthesia: Misunderstood, Misdiagnosed and Poorly Managed.

Approach to the Management of Scalp Dysesthesias

Fibromyalgia and the Scalp

There are many causes to consider in patients with underlying scalp dysesthesia. Cervicaal spine disease and underlying depression/anxiety have received some attention in the research world. However, there are many causes to consider.

Today, we’ll spend time talking a bit about fibromyalgia as a potential cause of scalp dysesethesia. Fibromyalgia is a chronic pain disorder with a well-defined clinical phenotype which affects about 2-4 % of people in the United States. The condition has several key features including widespread pain and tenderness, high levels of sleep disturbance, fatigue, cognitive dysfunction and emotional distress. Research over the past decade has shown that abnormal processing of pain and other sensory input occurs in the brain, spinal cord and periphery and is related to the processes of central and peripheral sensitization. As such, fibromyalgia is deemed to be one of the central sensitivity syndromes.

Neurogenic Inflammation in Fibromyalgia

The method by which nerve signals communicate appear to be disturbed in fibromyalgia. We now know that the brain and spinal cord don’t process information about pain sensations in a normal manner. Patients with fibromyalgia often feel pain. Stimuli that might not be painful to most people are interpreted by the brain of someone with fibromyalgia as painful. For example, a scalp massage might be considered painful by someone with fibromyalgia.

A special type of inflammation known as “neurogenic inflammation” may contribute to the symptoms that patients with fibromyalgia experience. For example, there is now evidence of neurogenically-derived inflammatory mechanisms occurring in the peripheral tissues, spinal cord and brain in fibromyalgia. Neuropeptides, chemokines and cytokines are proposed to be the chemicals that drive this inflammation and are postulated to be the activators of both the innate and adaptive immune systems.  This contributes to the clinical features of fibromyalgia, such as swelling and dysesthesia, and may influence central symptoms, such as fatigue and changes in cognition. In turn, emotional and stress-related physiological mechanisms are seen as upstream drivers of ‘neurogenic inflammation’ in fibromyalgia.

Scalp Dysesthesia in Fibromyalgia 

Individuals with fibromyalgia commonly experience a variety of scalp symptoms including itching, burning, pain, throbbing, shooting pains. For some it hurts to lay down on a pillow, brush the hair or even shampoo the scalp. These types of symptoms are much more common in fibromyalgia than we realized. Unfortunately, the symptoms are often ignored by the medical community or incorrectly diagnosed as dandruff, seborrheic dermatitis. All too common the sytmposm are attributed to anxiety or depression.

Despite being so common, scalp findings and symptoms in patients with fibromyalgia have not received much attention or study in the medical literatre. We don’t really have a good understanding of the types of symptoms patients with fibromyalgia experience. Some of the pain has been attributed to the tightening of scalp muscles, but I think this is far too simplistic of a view. Now that we understand more about neurogenic inflammation in fibromyalgia it becomes clear that these cytokines, chemokine and neuropeptides are likely to be directly responsible for creating the pain, itching, and burning in fibromyalgia. A variety of other pain syndromes may be associated with the same neurogenic inflammation - including such entities as chronic fatigue syndrome. Many such entities have associated scalp conditions but have been poorly studied and documented.

Treatment of scalp symptoms in Fibromyalgia

A variety of treatment options are available to address the scalp symptoms that occur in patients with fibromyalgia. It’s important for the physician treating the scalp symptoms to work closely with the rheumatologist to formulate a plan for treating the scalp symptoms. When I work with patients who have scalp symptoms, I generally correspond with the main fibromyalgia treating team.

Daily exercise and improving sleep as much as possible can help many people. Meditation techniques are helpful for some. There are hundreds of different types of meditation that are possible and there is no right or wrong way. Some of my patients with scalp pain simply find that turning on the TV helps take their mind off the symptoms (other patients of mind with fibromyalgia find the noise and light of the TV bothersome altogether so their is no one type of answer). Yoga, tai chi, prayer help many others. A variety of medications can be considered including gabapentin, Lyrica, and amitriptyline. Low dose naltrexone at 1.5 to 4.5 mg helps some patients with fibromyalgia-related scalp symptoms. Topical TKAL is proving helpful for some but not all individuals with fibromyalgia as sometimes rubbing creams into the scalp causes pain.

A variety of non pharmacological options are available including apple cider vinegar rinses, use of witch hazel and use of essential oils. Ice packs and frozen peas placed on the scalp or neck provide relief to many patients. Cool water placed on scalp also helps many as well.


A variety of scalp symptoms may be experienced by patients with fibromyalgia. These include burning, pain, itching, brushing, shoot pains and throbbing. These types of symptoms are poorly understood. Unfortunately they are all too often dismissed by health care providers or attributed to other reasons. Treating is challenging but a multifaceted approach often provides some degree of help.

Dr. Jeff Donovan is a Canadian and US board certified dermatologist specializing exclusively in hair loss. To schedule a consultation, please call the Whistler office at 604.283.1887

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